Up to 50% of women and 25% of men suffer from venous disease in western countries. The natural progression of venous disease leads to swelling, pain, skin changes, and often ulcers of the lower extremities. In the past, management of venous disease required hospitalizations and extensive surgeries—often with dismal outcomes. Now, with office-based evaluation and management, venous disease can be treated on an outpatient basis. Treatments have a very high success rates and complication rates less than those for IV antibiotic therapy. The risk of venous disease management has been greatly decreased, and the effectiveness of venous treatments now reaches close to 100%.